Sound Research WIKINDX

WIKINDX Resources

Zhang, J. (2013). Auditory cortex stimulation to suppress tinnitus: Mechanisms and strategies. Hearing Research, 295, 38–57. 
Added by: Mark Grimshaw-Aagaard (4/21/14, 10:07 AM)   
Resource type: Journal Article
Peer reviewed
BibTeX citation key: Zhang2013
View all bibliographic details
Categories: General
Keywords: Cognition, Tinnitus
Creators: Zhang
Publisher: Elsevier
Collection: Hearing Research
Views: 5/384
Brain stimulation is an important method used to modulate neural activity and suppress tinnitus. Several auditory and non-auditory brain regions have been targeted for stimulation. This paper reviews recent progress on auditory cortex (AC) stimulation to suppress tinnitus and its underlying neural mechanisms and stimulation strategies. At the same time, the author provides his opinions and hypotheses on both animal and human models. The author also proposes a medial geniculate body (MGB)-thalamic reticular nucleus (TRN)-Gating mechanism to reflect tinnitus-related neural information coming from upstream and downstream projection structures. The upstream structures include the lower auditory brainstem and midbrain structures. The downstream structures include the AC and certain limbic centers. Both upstream and downstream information is involved in a dynamic gating mechanism in the MGB together with the TRN. When abnormal gating occurs at the thalamic level, the spilled-out information interacts with the AC to generate tinnitus. The tinnitus signals at the MGB-TRN-Gating may be modulated by different forms of stimulations including brain stimulation. Each stimulation acts as a gain modulator to control the level of tinnitus signals at the MGB-TRN-Gate. This hypothesis may explain why different types of stimulation can induce tinnitus suppression. Depending on the tinnitus etiology, MGB-TRN-Gating may be different in levels and dynamics, which cause variability in tinnitus suppression induced by different gain controllers. This may explain why the induced suppression of tinnitus by one type of stimulation varies across individual patients.
WIKINDX 6.5.0 | Total resources: 1143 | Username: -- | Bibliography: WIKINDX Master Bibliography | Style: American Psychological Association (APA)