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Wesson, D. W., & Wilson, D. A. (2010). Smelling sounds: Olfactory–auditory sensory convergence in the olfactory tubercle. The Journal of Neuroscience, 30(8), 3013–3021. 
Added by: Mark Grimshaw-Aagaard (5/19/14, 2:27 PM)   Last edited by: Mark Grimshaw-Aagaard (9/28/15, 10:44 AM)
Resource type: Journal Article
Peer reviewed
DOI: 10.1523/JNEUROSCI.6003-09.2010
BibTeX citation key: Wesson2010
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Categories: General
Keywords: Mice, Modality, Smell, Smound
Creators: Wesson, Wilson
Collection: The Journal of Neuroscience
Views: 3/635
Historical and psychophysical literature has demonstrated a perceptual interplay between olfactory and auditory stimuli—the neural mechanisms of which are not understood. Here, we report novel findings revealing that the early olfactory code is subjected to auditory cross-modal influences. In vivo extracellular recordings from the olfactory tubercle, a trilaminar structure within the basal forebrain, of anesthetized mice revealed that olfactory tubercle single units selectively respond to odors—with 65% of units showing significant odor-evoked activity. Remarkably, 19% of olfactory tubercle single units also showed robust responses to an auditory tone. Furthermore, 29% of single units tested displayed supraadditive or suppressive responses to the simultaneous presentation of odor and tone, suggesting cross-modal modulation. In contrast, olfactory bulb units did not show significant responses to tone presentation nor modulation of odor-evoked activity by tone—suggesting a lack of olfactory–auditory convergence upstream from the olfactory tubercle. Thus, the tubercle presents itself as a source for direct multimodal convergence within an early stage of odor processing and may serve as a seat for psychophysical interactions between smells and sounds.
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